Best Liver Supplements for Sale on the Market [2021 Review]

A Review of the top liver detox pills available on the market today.

A healthy liver is crucial for survival. It protects your body by filtering out toxins while also having unique regenerative qualities that allow you to lose a piece and grow back. This is particularly helpful in organ donation.

Many people take supplements to improve liver health and boost its ability to operate at its best. The good ones target specific things like inflammation or focus on cleansing.

So what are the best on the market today and how can you choose for yourself? Here we hope to go over our ranking, how we got there, the science behind the active ingredients, and anything extra that comes up.

The Best Liver Supplements in 2021

Without further ado, here is our list of top liver supplements!

Organifi Liver Reset

Best Liver Supplements for Sale on the Market [2021 Review]

A popular one, Organifi’s Liver Reset, is a reputable brand and also one of the most cost-effective at a price just under $28 per month. It contains ingredients used to keep the liver healthy for centuries while maintaining dose transparency, including dandelion root (300 mg of the extract), artichoke leaf extract, Triphala (300 mg), and milk thistle (250 mg), and is transparent with its doses. Their ingredients are also organically sourced.

1MD LiverMD

Best Liver Supplements for Sale on the Market [2021 Review]

The most significant selling point of 1MD LiverMD is its easy availability. You can find it on Amazon, at Walmart, through other major retailers of supplements, and have an official website. It contains clinically proven ingredients like milk thistle extract, NAC, ALA, and more potent doses of minerals and vitamins. Despite a price tag of $45, they are one of the most popular supplements on this list, and 1MD offers an array of other supplements in their line as well. They are roundly considered one of the best supplement providers you can buy from.

Live Conscious LiverWell

Best Liver Supplements for Sale on the Market [2021 Review]

Live Conscious LiverWell supplement is marketed as happy liver, happy life. Two capsules a day of this supplement reportedly support the liver, aids detoxification, protects the liver, supports immune cell production, and supports metabolism using natural ingredients like milk thistle, NAC, and ALA. These bottles come in at $26 per month and are also considered quite affordable.

Amy Myers MD Liver Support

Best Liver Supplements for Sale on the Market [2021 Review]

Amy Myers MD Liver Support has a blend of ingredients, including 200 mg NAC, to help detoxify and optimize your daily liver function. It also helps scavenge free radicals through alpha-lipoic acid. They recommend a single capsule twice daily to receive the full benefits.

Zenith Labs Zenith Detox

Best Liver Supplements for Sale on the Market [2021 Review]

The doctor-formulated Zenith Detox supplement claims to assist phase 1 and 2 detoxification and supports healthy liver function. Taking it daily can also purportedly reduce joint aches, increase youthful appearance, increased confidence, improved physical stamina, and more- claims not generally seen with liver health supplements. Zenith Detox also includes some unusual ingredients, including Setria glutathione, L-methionine, and Schisandra berry extract.

Gundry MD Complete Liver Support

Best Liver Supplements for Sale on the Market [2021 Review]

Gundry MD’s Complete Liver Support has the title of the most affordable bottle on the list, at just $20 per month. Marketed as the “swiss army knife” of liver health supplements, they claim to not only support the liver it also supports the immune system, metabolism, your natural defenses and improves nutrient absorption. On top of the usual milk thistle and dandelion extracts, it also contains a strong dose of orange peel extract (1000 mg).

Advanced Bionutritionals Advanced Liver Support

Best Liver Supplements for Sale on the Market [2021 Review]

Advanced Bionutritionals Advanced Liver Support supplement requires four capsules per day to feel the full benefits. Using ALA, phosphatidylcholine, milk thistle extract, NAC, glycyrrhizin, and selenium, Advanced Liver Support reportedly supports the brain, liver, inflammation response and protects the liver from oxidative stress. While their ingredients are sourced globally, the product itself is manufactured in the United States.

PureHealth Research Liver Health Formula

Best Liver Supplements for Sale on the Market [2021 Review]

Pure Health Research’s Liver Health Formula supplement is specially formulated by a naturopathic doctor who claims it will “recharge your body’s youth battery” while giving “unlimited energy, trim waistline, and sharp thinking.” The active ingredients include alfalfa, beet, ginger, turmeric, artichoke extract, dandelion extract, and milk thistle extract.

ActivatedYou Morning Complete

Best Liver Supplements for Sale on the Market [2021 Review]

As the only supplement on this list not advertised as a liver health supplement, ActivatedYou Morning Complete is an all-in-one daily supplement containing prebiotics, probiotics, fiber, green superfoods, and more. Daily consumption of this wellness drink claims to help prevent oxidative stressors, support healthy blood sugar, support healthy liver function, support healthy cell function, and more.

VitaPost Liver Support Plus

Best Liver Supplements for Sale on the Market [2021 Review]

VitaPost’s Liver Support Plus is less than $28 per bottle and is also one of the few on this list sold through Walmart and other major retailers. Ingredients include milk thistle extract, beet, zinc, celery seed, artichoke seed, and more. However, its ingredients are at lower doses than other supplements. But at such a great value, it could potentially support your liver in small ways.

Phytage Labs Urgent Liver 911

Best Liver Supplements for Sale on the Market [2021 Review]

Phytage Labs’ Urgent Liver 911 is a nutritional supplement using beetroot, artichoke, celery seed, dandelion, and milk thistle extracts, with doses similar to Liver Support Plus. With 23 total ingredients, they claim to support overall liver health, flush fat from your liver, and reverse damage done to your liver. It is pretty pricey at more than $70 per bottle and doesn’t have a very high dose as many on this list.

How We Ranked The Best Liver Supplements

Liver health supplements all claim similar benefits, some more than others. But how can you sort the ones stretching the truth from the ones that may be helpful? Here are some practical guidelines:

  • Ingredients: Are there scientifically backed ingredients in this supplement? With a plethora of research on individual ingredients, you should require they contain at least some of them.
  • Dose: Does this supplement have a high enough dose to make a difference? Many supplements have very low doses of good things that are simply ineffective for their goal.
  • Doctors: Does this company have a medical advisory board to assist in the creation, and does the board include actual board-certified doctors? You’d be surprised how often the answer is no.
  • Advertisement: Are their advertised benefits too good to be true? There isn’t enough regulation in the supplement industry, so watch out for companies making big and bold claims. If they sound unrealistic, they probably are.
  • Manufacturer: Do they make it clear who they are, and is their manufacturing process transparent? This is vital when choosing to ingest something for health benefits. We have to decide who we trust carefully. Reputation counts for a lot in this area of business.
  • Price & Value: We all have different budgets, so we were sure to include supplements on opposite ends of the price spectrum to accommodate as large a pool of needs and budgets as possible.

Where The Science Stands

If you’re interested in the science, here is a concise list of studies on common liver health supplement ingredients to get you rolling:

Milk thistle

Its active ingredient (silymarin) has been shown in some lab studies to help regenerate liver tissue, reduce inflammation, and protect cells.

This study showed kids in the non-placebo group had slightly less liver damage after 28 days, despite undergoing leukemia treatment.

A 2017 review study found silymarin affected certain liver enzymes in people with liver disease.

A 2018 Cochrane review found it helped with cirrhosis, hepatitis B, and hepatitis C.

Artichoke leaf

Some studies show antioxidants in artichoke extract helping to protect the liver.

Another study on animals showed it aided in liver regeneration.

A 2018 study showed a tangible improvement in liver damage in patients with non-alcohol-induced liver disease.

Dandelion root

Despite no large-scale human trials, this 2006 profile on dandelion extract published in the Journal of Ethnopharmacology showed anti-inflammatory, anti-carcinogenic, and anti-oxidative properties.


A 2012 study showed daily zinc supplementation protects the liver from damage caused by hepatitis C viral infections.

Licorice root

This 2012 trial showed that the 379 people with chronic hepatitis C given this extract had marked improvement of their symptoms.

A study on rats showed a reduction in inflammation and fat retention in the liver caused by alcoholism.


This study found just 3 g of turmeric taken daily improved liver function.

Bonus: Signs of Early Liver Issues

Because the liver plays such a crucial role in normal body function, it’s important to recognize signs of a struggling liver as early as possible. If you do, you still have time to do something about it- or at least improve its longevity.

Some of the symptoms of a malfunctioning liver include Fatigue, weakness, exhaustion, nausea and/or vomiting, dark urine, gray stool, loss of appetite and weight loss, and discomfort in your abdomen on the right side just below your rib cage.

Know these signs and take care of yourself because you are valuable.

Advanced liver problems come with their signs and need to be addressed with a doctor immediately. These symptoms include bruising and bleeding easily, confusions or other cognitive issues, personality and mood shifts, memory loss, jaundice, and abdominal fluid retention.

Catching it early or later is vital to remaining alive and living well. Both are treatable in different ways if seen.

For some ways to reduce your odds of liver problems, you can:

  • Reduce Body Fat: It’s an uncomfortable truth that high-fat content in the body, while maybe not causing any health issues for you now, can start to affect the liver over time negatively. This is especially true if it is saturated fat as it helps lead to the creation of fat deposits around the liver and non-alcoholic fatty liver disease or NAFLD.
  • Supplements: Need I say more?
  • Reduce Alcohol Consumption: While the liver can’t filter alcohol, it is technically a poison. Frequent and sustained use over time will start to damage your body- including your liver. However, that doesn’t mean you can’t ever have it.
  • Quit Smoking: We often associate the lungs with smoking, but the truth is, it is connected to a host of health issues, and liver damage or inflammation is one of them.
  • Reduce Exposure to Toxins: Another self-explanatory one. This is a world full of toxins; take it easy on your liver by attempting to reduce exposure to them.
  • Avoid Hard Illegal Drugs: Hard illegal drugs like heroin and cocaine are directly linked to liver inflammation and damage.
  • Avoid Overusing Medications: We cannot help if we have health issues requiring lifelong medication use; you know who you are. But if you are not one of those people, avoid over-medicating yourself. Popular drugs that can lead to liver damage include acetaminophen, antibiotics, and anti-anxiety meds. I purposely left off ones that are more life and death, like cancer treatment.

The Best Liver Supplements in 2021 Last Words

As has been repeatedly stated, liver function is vital to our overall health. Studies show that various ingredients can improve liver function, and this list includes supplements with such ingredients.

If you’re looking to help support your liver for a longer, healthier life with it, then we highly recommend the above supplements. But remember- see a doctor if you have any signs of liver damage. Stay healthy!

RELATED: Urgent Liver 911 Reviews: Scam or Legit Liver Health Pills?

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The links contained in this product review may result in a small commission if you opt to purchase the product recommended at no additional cost to you. This goes towards supporting our research and editorial team and please know we only recommend high quality products.


Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.