Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

The liver is the second-largest organ in your body, and it performs over 500 functions. The liver is responsible for filtering harmful substances from the blood, breaking down toxins, producing bile for digestion, storing sugar, and more. Its exceptional capabilities mean that supporting your liver health is vitally important — especially as you age.

So it’s essential to take care of your liver every day — even if you don’t have liver problems. But if your liver isn’t functioning correctly, good supplements can help support and improve your health. These supplements contain concentrated amounts of herbs, minerals, and vitamins that target specific ailments of the liver.

The supplements below have stood out from the pack for their ability to cleanse your liver, support its functions, and prevent damage. They rank in order of effectiveness based on expert opinion and user reviews.

Table of Contents

The Best Liver Detox Pills in 2021

Thanks to the curation by our editorial team, you can confidently choose from any of the best liver detox pills in 2021 listed below. The supplements rank according to their effectiveness. Additionally, we have a description for each supplement for better understanding.

PureHealth Research Liver Health Formula

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

PureHealth Research’s Liver Health Formula is a ‘Best New Supplement’ that harnesses the power of natural ingredients to improve liver functionality and promote weight loss. This capsule formula was developed by an expert ND who has spent years studying and treating various liver conditions. The simple-to-take capsules can help you achieve overall health and wellness — improving your energy levels, reducing your body fat, and ensuring that you’re able to live life without chronic pain or fatigue.

Liver Health Formula is a unique blend of plant-based ingredients that supports liver health — and it’s affordable! With ginger, alfalfa, and beet, as well as turmeric, dandelion, milk thistle, and artichoke extract all in a single serving, Liver Health Formula can whip your livers into shape in no time. Treat yourself today—you deserve it!

Phytage Labs Urgent Liver 911

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

Urgent Liver 911 is a nutritional supplement that uses milk thistle extracts, beetroot, artichoke, dandelion, and celery seed to support liver health. Urgent Liver 911 is the only other supplement that offers all of the same ingredients in the proper dosages — making it an excellent option for anyone suffering from liver problems. Phytage Labs claims that those who take Urgent Liver 911 daily can give their liver 23 ingredients to support overall health.

The ingredients in this supplement can purportedly reverse damage to your liver, detoxify your body, and flush the fat that’s clogging it.

ActivatedYou Morning Complete

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

Health supplements can go one of two ways: either they take a specific angle and focus on one aspect of health or try to do everything and subsequently do nothing. ActivatedYou Morning Complete is the latter of these two options: it contains prebiotics, probiotics, fiber, B vitamins, green superfoods, immune-boosting ingredients, and other active nutrients — so it’s like having a multivitamin packed with extra goodies.

When you wake up in the morning, do you feel sluggish and tired? The water in your cells is more than likely dehydrated. Morning Complete is a potent daily wellness drink that helps replenish the electrolytes and fluids lost during the night so that you can start your day off right. Drink it every morning for consistent health benefits such as protection against oxidative stressors, support healthy liver and cell function, and help healthy blood sugar.

Gundry MD Complete Liver Support

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

One of the most affordable liver support supplements on the market, Complete Liver Support, is the Swiss Army knife for liver health. It can help improve nutrient absorption, support the immune system, support your metabolism, and support your body’s natural defense mechanisms against viruses and bacteria.

Complete Liver Support combines potent milk thistle and dandelion extracts with an ingredient we haven’t seen in other formulas: 100 mg of orange peel. The formula supports your liver’s health and fights against free radicals that damage your organs.

Amy Myers MD Liver Support

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

Myers MD Liver Support contains two ingredients that can help improve liver function: N-acetyl cysteine (NAC) and alpha-lipoic acid. NAC is a precursor to glutathione, which the liver uses to break down toxins. Alpha-lipoic acid helps your cells produce energy and helps protect you from free radicals — substances generated as a byproduct of exercising, smoking, and other activities.

Amy Myers MD, a world-renowned functional medicine doctor, recommends taking Liver Support twice a day for cleansing and detoxification. The potent blend of ingredients in this supplement boosts liver health, helping you to feel healthier and more energized every day.

Organifi Liver Reset

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

Organifi Liver Reset is from superfoods that have been used for centuries to support liver health. The formula includes 250 mg of milk thistle, artichoke leaf extract, 300 mg of dandelion root, and 300 mg of Triphala — which are all filled with antioxidants that fight free radicals and help your body’s systems work more effectively.

Organifi’s transparency with every ingredient is incomparable.

Zenith Labs Zenith Detox

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

Zenith Labs’ detox supplement puts the power of liver support into your hands. The company created this supplement using natural, plant-based ingredients like milk thistle, turmeric, and beetroot extract to increase the production of glutathione – a liver detoxifier. The supplement also assists with Phase 1 and 2 liver detoxification by supporting the structures that break down waste compounds.

According to the doctors behind Zenith Detox, the supplement has proven to help improve multiple aspects of your health. It can decrease joint pains, boost physical stamina, keep your skin looking young, and even make you more confident.

Live Conscious LiverWell

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

Live Conscious LiverWell is the natural liver extract you need to help your body in its daily detoxification process. Its main ingredient, milk thistle, is packed with nutrients that can aid liver health and support overall metabolism and energy levels. Thousands of people have seen great results from taking two capsules of LiverWell every day — and you will too.

LiverWell is a low-cost way to help you maintain liver health. Containing milk thistle extract, NAC, and ALA, all of which improve liver function, LiverWell is an easy way to ensure your life isn’t negatively affected by issues related to your liver.

Advanced Bionutritionals

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

Advanced Bionutritionals Liver Support supplement is a powerhouse of antioxidants, liver detoxifiers, and nutrients that help improve your liver health. It’s fortified with three different forms of alpha-lipoic acid plus selenium to support your liver in its efforts to detoxify your body and fight free radical production. It’s also an excellent source of phosphatidylcholine, which helps to restore liver cell membranes damaged by alcohol.

You can strengthen brain and liver health, maintain a healthy inflammatory response, and protect your liver from oxidative stress by taking four capsules daily. Look no further than Advanced Liver Support if you’re looking for a natural approach to lower your risk of oxidative stress-related diseases like Alzheimer’s or diabetes.

VitaPost Liver Support Plus

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

When shopping for supplements, it’s easy to get lost in the details of ingredients and stackability. Let’s face it, though — for most people, the price is a significant factor. VitaPost’s Liver Support Plus is one of the more affordable options on our list. At under $30 a bottle, anyone who needs liver support is reasonable enough for daily use.

Inside each bottle of Liver Support Plus are various ingredients, including milk thistle extract, beet, artichoke extract, and celery seed. Each element supports liver health at different stages in your body’s natural processes — from detoxing toxins to helping healthy blood vessels.

1MD LiverMD

Best Liver Detox Supplements: Top Liver Cleansing Pills 2021

1MD’s LiverMD is a unique and affordable supplement that combines powerful ingredients to help maintain the health of your liver. Its key component, milk thistle, has been used in several studies to have an antioxidant effect that protects liver cells from damage. In addition, the supplement also contains a hefty dose of N-acetylcysteine, which helps protect against acetaminophen toxicity — one of the leading causes of liver damage due to medications.

1MD is a health and wellness brand working to provide people with the tools they need to achieve their health goals. 1MD has spent a lot of time refining its products to provide the highest quality ingredients. LiverMD, for example, contains high doses of ingredients that are known to help promote liver health.

How We Ranked The Best Liver Detox Pills in 2021

Understanding how to choose a liver health supplement can be difficult. The market is flooded with options, each making claims to promote liver health. We used three key factors to separate the myriad of quality options: product ingredients, safety, and value.

Trusted ingredients

We examined thousands of studies to determine which ingredients have scientific proof to improve liver health. We only trusted supplements that used these ingredients to illustrate a complete understanding of how the human body processes supplements.

Clinically effective dosages

The best liver health supplements have dosages at the correct levels to impact the body positively. The best dosages are high enough to be clinically effective but not so high that they come with harmful side effects.


Doctors and health professionals have more experience with human beings than anyone else in the world. That’s why it’s so important to include them in the creation of supplements — their expertise, coupled with scientific research, can form the ideal formula for a potent and effective supplement. The best supplements use doctors to create the best quality product for your body.

Claimed benefits

Few products are miraculous enough to eliminate all of your toxic waste and cleanse your liver. Most detox supplements can’t even live up to the bold claims that companies make about them. They may say their product can help you lose 10 pounds in a month or help you improve cognitive function. These exaggerated claims are based more on hope than science, and they’re typically impossible to live up to.

We preferred supplement brands that deliver proven health benefits and support a positive lifestyle with honesty and integrity.

Manufacturer reputation

You’re likely to want products made by reputable manufacturers, particularly those who are transparent about their ingredients and production processes. When manufacturers are vague and secretive about their ingredient sources or manufacturing processes, it can indicate a lack of quality. That’s why we work with both long-standing supplements brands and new manufacturers that are open about their ingredient sources and manufacturing locations,

Price and value

No matter your budget, you should find a safe and effective liver health supplement that contains the ingredients you want. That’s why we built this site to help you find the best value products — so you can always get a good deal on a supplement that works for you.

Scientific Benefits of Liver Supplements

Evidence from thousands of years of traditional practices involving herbs, vitamins, minerals, and plants has demonstrated both the efficacy and safety of many of these ingredients. The following section reviews the scientific literature to determine which components are most promising for liver health.

Milk thistle

Milk thistle is one of the oldest and most popular ingredients in liver health supplements. People have lived by the milk thistle plant for thousands of years, and it didn’t take long for them to discover its incredible abilities. Today, doctors recommend milk thistle to their patients as a safe, natural alternative to treat liver damage and support overall liver health. Milk thistle contains silymarin, an active ingredient that has a positive effect on liver health. When supplemented with other herbs and dietary modifications, silymarin can reduce liver damage from alcohol consumption or help treat certain types of Hepatitis.

Although milk thistle (Silybum marianum) extract has been promoted as a liver health supplement, it appears to be more effective than previously observed in numerous human studies. For example, in one study, researchers gave milk thistle to children treated with chemotherapy and compared its effects to placebo. Kids in the milk thistle group did have higher levels of certain liver enzymes at the end of the trial.

The amount of scientific studies conducted on silymarin, the active ingredient in milk thistle extract, is astounding. It’s been shown to affect specific liver enzymes and markers of liver damage in people with liver disease; it’s also been used by patients with cirrhosis, hepatitis B, and even hepatitis C.

Artichoke leaf

Antioxidants are potent chemicals that help protect the body from disease by combating harmful free radicals. Many people turn to antioxidant supplements for liver health. In particular, the artichoke leaf extract is rich in antioxidants. In one study on animals, researchers found that artichoke extract could help liver cells regenerate after injury — so if your liver cells are damaged (which can happen with excessive alcohol use), this supplement could be beneficial.


The dandelion, a flowering plant in the sunflower family, is ideal for supporting liver health. Chinese herbalists have used it for thousands of years to help treat jaundice and other liver problems. Although dandelion root has been credited with an impressive number of health benefits, it is often overlooked in today’s supplements market. One reason is that dandelion root has not undergone rigorous testing in human trials.

It may surprise you to learn that dandelion has been studied extensively for its anti-inflammatory, anti-oxidative, and anticarcinogenic properties. In a 2006 study published in the Journal of Ethnopharmacology, researchers concluded that dandelion root, when used topically or orally in small doses, may have a positive health benefit. However, more rigorous research is required to quantify these results.

Licorice root

In a 2012 trial, researchers gave a popular natural licorice root extract to 379 people with chronic hepatitis C. They found that those who took the extract experienced fewer symptoms of hepatitis C compared to the control group. Research has shown that a compound in licorice ( glycyrrhizin) can reduce alcohol-induced inflammation in the liver in rats. Another study looked at how fat accumulation is affected by glycyrrhizin in rats. The results showed that the rats treated with glycyrrhizin gained less weight and had lower triglycerides and cholesterol levels than those treated with a placebo.

Heavy consumption of licorice could be unsafe because some licorice supplements use glycyrrhetinic acid, a compound that’s harmful to the body. Therefore, many brands of licorice extract supplements list Deglycyrrhizinated licorice (DGL) as an ingredient.


Curcumin, an active component in turmeric, is mainly known for its anti-inflammatory and liver-health-promoting properties. In this experiment, researchers have found that taking 3g of curcumin daily resulted in improved liver health. Turmeric supplementation reduces ALT and AST levels without adverse reactions. While many supplements have adverse reactions, this supplement did not, suggesting it may help improve liver disease.

Yellow dock root

Yellow dock root is not a household name, although it contains many antioxidants and should be included in your diet because of its nutritional value. The root vegetable can support digestive health because of its high fiber content, which directly impacts the gut and digestive tract. It’s most commonly found in Essiac tea, a traditional drink full of herbs and nutrients that have been used for centuries to fight cancer and detoxify the blood.

Diuretic herbs help users lose weight by flushing away excess water and waste from the body, reducing bloating and water retention. Yellow dock root is a diuretic that encourages more frequent urination, which promotes faster waste removal. It also stimulates peristalsis and enhances mucus secretion and water in the colon, enabling waste to be expelled from the body rapidly.

Beetroot, ginger, choline, molybdenum, selenium, alpha-lipoic acid (ALA), and other ingredients have all been cited in numerous studies about liver health. Be sure to find a probiotic that’s suitable for your needs — some supplements feature a wide variety of ingredients while others focus on dosages of a few essential compounds.

Early Symptoms Associated With a Malfunctioning Liver

If you have liver problems, you don’t always know it. Your liver is an organ that usually does its job quietly and efficiently, but when it doesn’t, your body suffers greatly. A damaged liver can lead to severe issues, some of which are subtle and go unnoticed for a long time. If you’re not sure whether your liver health is where it should be, watch out for the following symptoms :

  • Nausea, vomiting, loss of appetite
  • Jaundice (yellowing skin and eyes) feels like you’ve been drinking too much
  • Fluctuating Liver-health-promoting defense weight, a swollen stomach
  • Fatigue that won’t go away
  • Tenderness when your abdomen is touched
  • Dark-colored urine or pale stool

Advanced liver problems can lead to more severe symptoms. Bleeding could occur through nosebleeds, blood in your urine and feces, or internal bleeding, leading to blood in vomit, sputum, and coughing up blood. Fluid retention can cause swelling of the legs and abdomen. If you experience any of the above symptoms for longer than a few weeks, visit your doctor right away to rule out liver damage.

How to Improve Your Liver Health

You’ve got a lot on your plate. You’re surrounded by toxins daily, and now is an excellent time to focus on strengthening your liver. We all have various remedies overwork but don’t forget these pro-science-backed tips to boost your liver health.

Cut down fat

Saturated fats are bad for your heart and overall health and can cause severe damage to the liver. Consuming unhealthy fats is associated with nonalcoholic fatty liver disease (NAFLD), a condition in which the liver becomes clogged with fat deposits that reduce overall organ function. Avoiding foods high in saturated fat can help prevent NAFLD and other diseases — not to mention it can lead to weight loss.

Eat a balanced diet

Instead of getting your calories from an excess of processed food, including packaged snack foods and pastries, get your daily dose of nutrients from healthy whole foods. By eating nutrient-rich fruits and vegetables, whole grains, lean proteins, and healthy fats — you’ll be able to get all the energy you need to keep moving and improving your health.

Limit Alcohol

Drinking alcohol in moderation is an essential step towards an energized defense, healthy liver. When you drink, your liver metabolizes the alcohol you consume — essentially turning it into poison that’s slowly released into your bloodstream over time. Unfortunately, many people develop health problems as a result. These could include a host of issues, including liver damage and even cancer. Keep your drinking habits safe with these expert tips.

Take a Supplement

To ensure you’re taking the best possible supplements for your liver (and your health in general), try any of the products listed above. Each of these supplements offers a unique way to support liver health, from detoxification to inflammation management.

Avoid toxins

Be mindful of what you’re using in and around your home. Most household cleaning products are packed with harsh, environmentally unfriendly chemicals that can damage the liver when inhaled or absorbed through the skin. Always remember to use a mask while using aerosols and ventilate rooms when possible.

Follow directions on all medications

Know the details of each prescription you take, and always follow your doctor’s advice. Take only the amount of medicine that’s been prescribed to avoid interactions or overdosing, and never combine it with alcohol or other drugs, even those available over-the-counter.

Minimal smoking

Smoking cigarettes causes damage to your body from the inside out. The tar, chemicals, nicotine, and carbon monoxide in tobacco smoke go through your lungs into your bloodstream and then settle in your organs. Your liver has to overwork to filter these toxic substances from your body every time you smoke, creating inflammation that leads to some health issues, including a suppressed immune system and liver damage.


Exercise regularly for a healthy body. Routine exercise helps fuel the body and reduces liver fat, leading to a healthier body.

Do not use illicit drugs

Illegal drugs do not belong in your home. These include marijuana/hashish, cocaine (including crack), heroin, hallucinogens, inhalants, or prescription-type drugs without a proper prescription from a medical doctor. In addition to the physical damage that these can cause, they can create significant legal problems for you and others in the household.

Liver Health Supplements FAQs

Q: What’s a liver?

A: Your liver is an organ that serves as the body’s primary filtration system — activating all of your body’s major metabolic functions. When the liver isn’t effectively clearing toxins from the blood, you could experience a wide range of symptoms, from fatigue and cognitive impairment to muscle pain and abdominal discomfort.

Q: What’s a liver supplement?

A: Liver supplements are formulated with natural ingredients and compounds to support the health of your liver. They may help to stimulate liver function, dissolve plaque, or rid your body of toxins.

Q: What can liver supplements do for me?

A: For many people, liver health supplements are an excellent way to support their general health. These supplements offer potential benefits to your immune system, blood sugar levels, and even memory.

Q: What’s the correct dosage for liver supplements?

A: Liver health supplements come in two primary forms: capsules and powders. Capsules are the more popular option — they’re easier to swallow, and many people find them more convenient than drinking a powder. Powders are used with water or other beverages to make a shake but can also be used on their own or even sprinkled on food. Regardless of which form you choose, follow your doctor’s instructions regarding dosage and length of treatment.

Q: What’s the most effective liver health supplement?

A: The best liver health supplement is an entirely subjective question. External factors can sway the answer, such as personal dietary needs, your budget, and any conditions you’re trying to address. What works for a colleague may not work for you, and vice versa.

Q: What’s the function of a liver in the human body?

A: The liver has several vital functions. It’s responsible for:

  • Restructuring proteins, fats, and sugars from food
  • Processing alcohol and medications
  • Producing essential blood-clotting chemicals. Destroying old red blood cells
  • Breaking down and metabolizing nutrients absorbed by the intestines

Q: What’s the leading cause of liver damage?

A: The leading causes of liver damage are:

  • A poor diet
  • Heavy alcohol consumption
  • Smoking
  • Prescription or over-the-counter drugs in excess
  • Harmful effects of Hepatitis

Q: Is liver disease hereditary?

A: Scientists have identified many genetic markers that increase people’s chances of developing liver disease. However, food and lifestyle factors also play a role, so the best defense is to avoid liver disease altogether by eating healthy.

Q: Is alcohol the only cause of liver damage?

A: Many ways can harm your liver besides alcohol consumption — with the main culprit being improper diet. An unhealthy diet and lack of nutrients can cause oxidative stress on your liver, causing it to harden over time. Consuming a high-fat diet can also contribute to fatty liver disease or nonalcoholic steatohepatitis.

Q: How can I detox my liver?

A: Some people naturally detoxify their liver by following a healthy diet for a few days or weeks. Others take supplements. Some just remove toxic foods or habits. Juice cleanses and liver-supporting exercises can also work wonders.

Q: How do I know I have liver disease?

A: Liver disease is easily hidden. For all of its signs, symptoms can be subtle and often seem apparent. A patient may not know they have it until more severe complications occur. Your doctor can run tests to determine if you have liver disease, which they can do by checking your blood for harmful proteins that signal liver problems.

Q: What is cirrhosis?

A: Cirrhosis is the last stage of chronic liver disease. It’s a condition in which scar tissue inside the liver builds up, preventing the organ from functioning correctly. As scar tissue continues to form and accumulate, it can lead to complications and eventually liver failure or death.

Q: Should I perform a liver detox regularly?

A: A liver detox will not likely improve the function of your liver. If your liver is healthy, it should already be detoxifying your body. However, a detox offers other health benefits that could be useful for those with specific medical needs. For example, some cleanse to support the immune system or help overcome food addictions.

Q: Can I reverse liver damage?

A: The liver is the only organ in the body that can regenerate itself, unlike other organs replacing their damaged tissue with a scar. When one part of the liver is damaged, another part can grow to replace it.

Q: Do liver supplements work?

A: Liver health supplements may work. The compounds found in popular liver health ingredients, including milk thistle, turmeric, and artichoke extract, have been indicated to help fight liver inflammation. When complemented with a healthy diet and other natural remedies for liver support, liver health supplements can be the key to reducing liver damage caused by illness or injury.

Q: Is taking liver supplements safe?

A: Liver supplements are safe to take when following the recommended dosage. Make sure to consult your doctor before you take any supplements.

Q: Can supplements harm my liver?

A: When following recommended dosages, supplements are unlikely to put too much strain on your liver. However, 20% of liver injuries in the United States are linked with herbal dietary supplements — and if you don’t follow the recommended dosage, taking too much may harm your liver health.

Q: What is fatty liver?

A: Fatty liver is a reversible condition that’s also known as steatosis. It happens when your body stores extra fat in the liver cells. This excess fat makes the cells swell and starts to harm the tissue of the liver.

Q: What is NAFLD?

A: Nonalcoholic fatty liver disease (NAFLD) is a condition where fat builds up within the liver cells. While NAFLD is not an alcoholic ailment, it can lead to severe liver issues if left untreated.

The Best Liver Detox Pills in 2021 Final Words

Liver conditions affect millions of people every year. And although there are several ways to treat them, side effects and poor health can be a thing of the past by taking the right supplements. However, like any medication, the top liver supplements have instructions to follow and a recommended dosage.

ALSO READ: Best Immunity Booster Supplement for a Healthy Immune System

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Please understand that any advice or guidelines revealed here are not even remotely a substitute for sound medical advice from a licensed healthcare provider. Make sure to consult with a professional physician before making any purchasing decision if you use medications or have concerns following the review details shared above. Individual results may vary as the statements made regarding these products have not been evaluated by the Food and Drug Administration. The efficacy of these products has not been confirmed by FDA-approved research. These products are not intended to diagnose, treat, cure or prevent any disease.